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Cell & Gene Therapies
CAR‑T, CRISPR, in vivo delivery, manufacturing, and long‑term follow‑up.
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Latest in Cell & Gene Therapies
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for
26+ min ago (75+ words) Immune checkpoint inhibitors have transformed the treatment landscape for many cancers, yet a stubborn fraction of patients either never respond or relapse after an initial benefit. The central obstacle in these refractory cases is T-cell exhaustion: tumor-fighting CD8+ T cells that…...
Deadly Wheat Fungus Reveals a Hidden Molecular Switch That Controls Its
45+ min ago (96+ words) Scientists have uncovered a previously hidden partnership inside one of the world’s most destructive crop pathogens, and the discovery could reshape how farmers fight a disease that devastates wheat harvests and poisons grain supplies. A research team working on Fusarium…...
Second CAR T-Cell Infusion Hits Myeloma After CELMoD Bridging
1+ hour, 26+ min ago (475+ words) A case report from German hematologists suggests that patients with advanced multiple myeloma may still benefit from a second BCMA-directed CAR T-cell therapy, even after their disease has progressed following a first such treatment....
CAR-T Clinical Trial Pipeline Gains Momentum: 180+ Companies Lead the Charge in Pioneering New Treatments | DelveInsight
2+ day, 12+ hour ago (60+ words) CAR-T Clinical Trial Pipeline Gains Momentum: 180+ Companies openPR.com CAR-T Clinical Trial Pipeline Gains Momentum: 180+ Companies Lead the Charge in Pioneering New Treatments | DelveInsight Press release from: ABNewswire Permanent link to this press release: You can edit or delete your…...
CRISPR Activation Tool Uncovers Genes Linked to Lymphoma Drug Resistance
2+ day, 11+ hour ago (505+ words) Inside Precision Medicine A new whole-genome CRISPR screening platform has helped researchers identify a previously unknown gene causing lymphoma cells to become resistant to a widely used cancer drug, as well as several genes that can accelerate tumor growth. Published…...
Christ Hospital trial targets genetic fix for high cholesterol
2+ day, 7+ hour ago (21+ words) WCPO 9 News Christ Hospital trial targets genetic fix for high cholesterol...
Gene that drives blood cancer drug resistance uncovered with new CRISPR activation tool
2+ day, 11+ hour ago (437+ words) Researchers used a powerful new guide RNA library, Partita, to find genes that help lymphoma cells escape treatment and accelerate tumor growth image: L-R: Dr Eddie La Marca, Prof Marco Herold; L-R: Dr Yexuan Deng, Dr Margaret Potts, Dr Sarah…...
CRISPR Tool Unveils Gene Behind Blood Cancer Drug Resistance
2+ day, 11+ hour ago (338+ words) GLOBAL: Researchers have uncovered a previously unknown gene causing resistance to a leading blood cancer drug and several genes that accelerate lymphoma growth by using a powerful new CRISPR activation library. Traditional CRISPR is a genetic engineering tool that allows…...
iPSC-derived CAR γδ T cells for liver cancer
2+ day, 18+ hour ago (374+ words) Autologous chimeric antigen receptor (CAR) T cell therapies are now a part of standard treatment protocol for hematological malignancies. Despite this, they are deeply constrained by elevated costs and delayed access for patients. Allogeneic donor-derived CAR T cells make off-the-shelf…...
Study shows reprogramming thyroid tumors may improve CAR-T cell therapy
2+ day, 18+ hour ago (592+ words) ROCHESTER, Minn. — Mayo Clinic researchers have identified a strategy that could help chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, overcome a major barrier to treating solid tumors: Cancer cells can change in ways that allow them to hide…...